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BIOL122 Human Biological Science

Questions:

1. Identify one disease/condition Cheryl has and justify your answer.

2. Using the disease/condition you have identified in explain the linkbetween the clinical manifestations of the disease and its pathophysiology.

3. Discuss the benefits of administration of an SSRI in Cheryl’s condition. To get full marks, you must explain the pharmacodynamics and pharmacological effects ofSSRIs and relate them to Cheryl’s clinical picture.

4. Describe the effect of chronic alcohol consumption on liver function and explain itsconsequence on the distribution of water between the interstitial and intravascularcompartments.

5. Name the musculoskeletal disorder Rose suffers from, justify your answer, and identify a risk factor in her history that is specific to the disease you specified.

6. Compare and contrast the aetiology of Rose’s joint disease with the other joint disease we covered in. In your answer, name both diseases and describe two similarities and three differences.

7. Interpret the result of the bone density measurement, indicate what reading would be considered physiological, and name the condition Rose’s finding is associated with.

8. Describe the aetiology and pathogenesis of the disease you specified in the previous question.

9. Name and define the type of fracture you identified in Rose’s case and describe the most likely link between the condition you named under and her vertebral fracture. 

10. Based on what you learnt about vaccinations and infection control in and using any other sources of information you deem relevant and reliable, describe your answer to Cheryl and justify your conclusion.

11. State four pieces of evidence from Greg’s clinical picture/laboratory findings that support the GP’s suggestion.

12. Name the complication Greg was suffering from when he visited his GP and identify two laboratory or clinical findings that support your conclusion.

13. Identify the type of diabetes Greg is suffering from and justify your answer.

14. Explain the link between Greg’s present condition and his breathing pattern. In your answer, you must also (i) name the characteristic breathing pattern observed in Greg’s case and (ii) explain the consequence of this type of breathing.

15. One of the long-term complications of Greg’s condition is accelerated rate of atherosclerosis. Explain three reasons for the increased rate of atherosclerosis in diabetic patients.

16. Assuming that Greg’s present state is related to his plasma glucose concentration, identify the reason for Greg’s unconscious state and outline the best course of action in the present scenario. Greg’s work colleague, Cindy, is a 38-year-old married mother of three girls, who was diagnosed with stage 3 infiltrating ductal cancer of her left breast. Cindy underwent left mastectomy and axillary lymph node dissection 7 weeks ago and is currently undergoing chemotherapy.

17. Describe three cancer cell characteristics that allow them to become invasive and metastatic.

18. Discuss three potential clinical manifestations that can result from bone marrow suppression and explain how this condition may be linked to Cindy’s treatment.

19. Considering their most likely aetiology, name the types of swelling in Cindy’s right hand and left arm and describe three differences between them.

20. List two factors that could have triggered Lisa’s acute asthma attack and explain the link between the named factors and her asthma.

21. Explain the pathophysiological steps leading to acute asthma attack. In your answer, you are expected to link type 1 hypersensitivity reaction to the role of histamine in acute asthma.

22. Briefly explain the mechanisms of action of (i) salbutamol and (ii) corticosteroids in the treatment of acute asthma and describe their benefits in Lisa’s condition.

23. Explain the mechanism of action of anticholinergic/anti-parasympathetic medications and their potential benefit(s) in asthma treatment.

24. Explain what Maria’s blood pressure readings suggest and discuss two risk factors that might have contributed to Maria’s present condition.

25. Explain the expected benefits of ACE inhibitors in the above case study by referring to their pharmacodynamics and pharmacological effects.

26. Name the condition Maria was suffering from when she was rushed to hospital and discuss two clinical findings that support your claim.

27. Based on the above properties of the drug, explain why you would recommend dose reduction in Maria’s case. In your answer, explain four age-related changes in the pharmacokinetics of MedX to justify why dose reduction is necessary in the present scenario. For each of those age-related changes described, you will need to consider how the free plasma concentration of the drug is expected to change in Maria’s case compared to that of a young or middle-aged individual.

BIOL122 Human Biological Science

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